| abstract |
Diastereomeric 5 R ,6 S -6-(1 R -hydroxyethyl)-2-(1 S -oxo-3 R -thiolanylthio)-2-penem-3-carboxylic acid and 5 R ,6 S -6-(1 R -hydroxyethyl)-2-(1 R -oxo-3 S -thiolanylthio)-2-penem-3-carboxylic acid, and pharmaceutically-acceptable salts and in vivo hydrolyzable esters thereof, useful as systemic antibacterial agents; and intermediates and processes which are useful in the said synthesis of said diastereoisomers. |