Predicate |
Object |
assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c81d97576dbeeb2b3e24fb19792da2e1 |
classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F9-142 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H21-00 |
classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F9-142 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H1-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H21-00 |
filingDate |
1988-06-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_49548b4a8c352ed57a4c2b441a2dbd11 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e8c3a6df55b778b81fc843cb2d6712c6 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d3ae2f01fa73cb255d64449b35e66700 |
publicationDate |
1988-12-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber |
EP-0294196-A2 |
titleOfInvention |
Chemical capping by phosphitylation during oligonucleotide synthesis |
abstract |
A method is provided for capping failure sequences in oligonucleotide synthesis by phosphitylation. A phosphite monoester is reacted with the 5′ or 3′ hydroxyl of the failure sequence between successive condensation steps in a synthesis procedure to form a 5′ or 3′ phosphite diester with the failure sequence. The phosphite diester substituent is inert with respect to subsequent reaction steps in the synthesis of the desired oligonucleotide product. |
isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1066308-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7273933-B1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0552766-A3 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-2277886-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8309710-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0552767-A3 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1066308-A4 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5646261-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6107479-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1729131-A2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8642755-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6033909-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8273304-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-9820018-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6451998-B1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9169286-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7247337-B1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0552766-A2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0552767-A2 |
priorityDate |
1987-06-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type |
http://data.epo.org/linked-data/def/patent/Publication |