http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0294196-A2

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http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H21-00
filingDate 1988-06-02-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_49548b4a8c352ed57a4c2b441a2dbd11
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e8c3a6df55b778b81fc843cb2d6712c6
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publicationDate 1988-12-07-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber EP-0294196-A2
titleOfInvention Chemical capping by phosphitylation during oligonucleotide synthesis
abstract A method is provided for capping failure sequences in oligonucleotide synthesis by phosphitylation. A phosphite monoester is reacted with the 5′ or 3′ hydroxyl of the failure sequence between successive condensation steps in a synthesis procedure to form a 5′ or 3′ phosphite diester with the failure sequence. The phosphite diester substituent is inert with respect to subsequent reaction steps in the synthesis of the desired oligonucleotide product.
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