| Predicate |
Object |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K48-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2740-13043 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-86
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-1077
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-45 |
| classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12R1-92
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12R1-91
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K48-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-867
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N7-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-45
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P21-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-09 |
| filingDate |
1988-05-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate |
1990-09-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
EP-0293193-A3 |
| titleOfInvention |
Gene transfer for drug resistance |
| abstract |
A method for sensitizing mammalian tumor cells nwhich comprises the step of inserting a drug sensitivity ngene into the tumor cell. Also disclosed is the use of nhypoxanthine phosphoribosyltransferase for the treatment nof leukemia when the drug 6-thioguanine is used. The method nemploys a composition of matter which includes a 3′ long nterminal repeat and a 5′ long terminal repeat, each repeat ncontaining a restriction enzyme site; between the repeats nis inserted a promoter and/or enhancer gene and the drug nsensitivity gene. All of the elements of the DNA are nlinked and spatially positioned, such that, when the gene nis inserted into a target cell the drug sensitivity gene nis expressed. |
| priorityDate |
1987-05-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |