Predicate |
Object |
assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_4254532e2a8f5fb1e71bc0f0f0e2b141 |
classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K48-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2740-13043 |
classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-45 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-1077 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-86 |
classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K48-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12R1-91 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12R1-92 |
classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-867 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N7-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-09 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P21-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-45 |
filingDate |
1988-05-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f561b2f4b994ab36d70eaf5ddb92e104 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e30d5e5d9ae8340709038619e5e78fc7 |
publicationDate |
1988-11-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber |
EP-0293193-A2 |
titleOfInvention |
Gene transfer for drug resistance |
abstract |
A method for sensitizing mammalian tumor cells which comprises the step of inserting a drug sensitivity gene into the tumor cell. Also disclosed is the use of hypoxanthine phosphoribosyltransferase for the treatment of leukemia when the drug 6-thioguanine is used. The method employs a composition of matter which includes a 3′ long terminal repeat and a 5′ long terminal repeat, each repeat containing a restriction enzyme site; between the repeats is inserted a promoter and/or enhancer gene and the drug sensitivity gene. All of the elements of the DNA are linked and spatially positioned, such that, when the gene is inserted into a target cell the drug sensitivity gene is expressed. |
isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-9618737-A2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-9618737-A3 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6699690-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6335009-B1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6555370-B1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0415731-A2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0657541-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0657539-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0415731-A3 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0690129-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6337209-B1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6300490-B1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-9208796-A1 |
priorityDate |
1987-05-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type |
http://data.epo.org/linked-data/def/patent/Publication |