abstract |
A method for producing IFN-beta in an animal host cell is described. The IFN-beta isolated in high yield from the cell supernatant has a specific activity of approx. 3.8 x 10⁸ IU / mg protein. Biological and immunological tests show that the isolated IFN-beta is largely identical to the natural IFN-beta. The IFN-beta produced by the described method is 95% glycosylated, the structure and sequence of the glycosylation largely matching that of natural IFN-beta, but without being identical to it. |