| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_3b5e38bcb266bbb0dd3a185e38d3a505 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-565
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-567
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-2031
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-006 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-20
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J1-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-565 |
| filingDate |
1988-04-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_76fe08faeb27d43b04854aab34faea48
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9a186f611115ee5c3771b758ff566d79 |
| publicationDate |
1988-10-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
EP-0286581-A1 |
| titleOfInvention |
Buccal administration of estrogens |
| abstract |
An adequate blood plasma level of 17-beta-estradiol or ethinyl estradiol is attained in a patient in need of estrogen therapy by administration of a dose of 17-beta-estradiol or ethinyl estradiol or a pharmaceutically acceptable ester thereof not greater than 150 micrograms into the vestibule of the buccal cavity of the patient and maintaining the dose in contact with the oral mucosa for a period of time sufficient for transmucosal absorption of a sufficient amount of estrogen to produce a therapeutically effective plasma concentration of estrogen. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11666585-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2010089078-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2007146805-A3
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6977083-B1 |
| priorityDate |
1987-04-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |