http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0286575-A2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_da54f7ebbd2d9d8a82f92aca4d1b4e48 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D457-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D457-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D457-12 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D457-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D457-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D457-04 |
| filingDate | 1988-03-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1fdf384a01aaa8149c9ab1385fc523ad http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_641bd98214f888a5bd9c931fa2110d38 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d5a4df086b66df1b3f5dd50a9bd36a83 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_216749dd6df0afe93e8200222674ee92 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5207ac049a0a8216783322f98bbe2688 |
| publicationDate | 1988-10-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-0286575-A2 |
| titleOfInvention | Process for the preparation of 2,3-beta-dihydroergolines, 2-substituted 2,3-beta-dihydroergolines and their use as medicaments |
| abstract | R 2 Wasserstoff oder C 1-4 Alkyl, R 6 Ci- 4 Alkyl und R 8 Methyl, Carboxymethyl, Ureido oder N, N-Diethylureido in a-oder β-Stellung und C 9 - 10 eine Einfach- oder Doppelbindung bedeutet, dadurch gekennzeichnet, daß man ein Ergolinderivat der allgemeinen Formel IIn worin R 2 , R 6 , R 8 und C 9 C 10 die oben genannte Bedeutung haben in Gegenwart einer Säure und eines H 2 -Edelmetallkatalysators oder Organylsilans reduziert und neue 2 substituierte 2,3ß-Dihydroergoline sowie deren Verwendung zu Herstellung eines Arzneimittels. A new process for the preparation of 2,3β-dihydroergoline derivatives of the general formula I is described, wherein R 2 is hydrogen or C 1-4 alkyl, R 6 Ci 4 alkyl and R 8 is methyl, carboxymethyl, ureido or N, N-diethylureido in a-or β-position and C 9 - 10 represents a single or double bond, characterized in that an ergoline derivative of the general formula II wherein R 2 , R 6 , R 8 and C 9 C 10 have the abovementioned meaning reduced in the presence of an acid and an H 2 noble metal catalyst or organylsilane and new 2 substituted 2,3ß-dihydroergolines and their use for the manufacture of a medicament. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0429153-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5158957-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0351352-A2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0351352-A3 |
| priorityDate | 1987-03-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 200.