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filingDate 1988-03-31-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6ed7c6dae25d709df001c53acbb67a68
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publicationDate 1988-10-12-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber EP-0286516-A1
titleOfInvention Amino-5,6,7,8-tetrahydro-naphtho[2,3b]furan derivatives, processes for their preparation and pharmaceutical compositions containing them
abstract - R 1 représente un atome d'hydrogène ou, à condition toutefois que le radical amino soit en position 7, un radical alkyle linéaire ou ramifié refermant 1 à 4 atomes de carbone, - R 2 représente un atome d'hydrogène ou, à condition toutefois que le radical amino soit en position 6, un radical alkyle linéaire ou ramifié renfermant 1 à 4 atomes de carbone, - R 3 et R 4 identiques ou différents représentent chacun un atome d'hydrogène, un radical benzyle, un radical cyclohexylméthyle, un radical alkylène linéaire ou ramifié renfermant de 1 à 5 atomes de carbone, un radical alkyle linéaire ou ramifié renfermant de 1 à 10 atomes de carbone (éventuellement substitué par un radical hydroxy, par un radical carboxy ou par un radical alcoxy de 1 à 5 atomes de carbone, par un radical alcoxy carbonyl de 2 à 6 atomes de carbone, par un radical alkyle phényle ou par un radical alkyl thiényle-2), un radical alkyle halogéné de 1 à 5 atomes de carbone, ou forment ensemble avec l'azote auquel Ils sont attachés un radical oxo-2 pyrrolidinyl-1, - A-B représente avec l'oxygène auquel il est attaché un radical éthylènoxy, un radical éthynylénoxy, un radical oxo-2 oxy-1 éthylène ou un radical hydroxy-2 oxy-1 éthylène. Médicaments. Compounds of general formula I, in which : R 1 represents a hydrogen atom or, provided, however, that the amino radical is in position 7, a linear or branched alkyl radical containing 1 to 4 carbon atoms, R 2 represents a hydrogen atom or, provided, however, that the amino radical is in position 6, a linear or branched alkyl radical containing 1 to 4 carbon atoms, - R 3 and R 4, which are identical or different, each represent a hydrogen atom, a benzyl radical, a cyclohexylmethyl radical, a linear or branched alkylene radical containing from 1 to 5 carbon atoms, a linear or branched alkyl radical containing from 1 to 10 carbon atoms (optionally substituted by a hydroxy radical, by a carboxy radical or by an alkoxy radical of 1 to 5 carbon atoms, by an alkoxy carbonyl radical of 2 to 6 carbon atoms, by an alkyl phenyl radical or by a alkyl thienyl-2) radical, a halogenated alkyl radical of 1 to 5 carbon atoms, or form together with the nitrogen to which they are attached a 2-oxo pyrrolidinyl-1 radical, - AB represents with the oxygen to which it is attached an ethylenoxy radical, an ethynylenoxy radical, a 2-oxo-1-ethylene radical or a 2-hydroxy-1-oxyethylene radical. Medicines.
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