| abstract |
There are disclosed sustained release tablets. They comprise a therapeutically active hygroscopic or non-hygroscopic therapeutic agent and a carrier base material, comprising hydroxypropylmethylcellulose having a methoxyl content of 28 to 30 weight-%, a hydroxypropoxyl content of 7.5 to 12 weight-% and an average molecular weight of at least 50 000 in a proportion of about 20 to about 40 weight-% of the tablet, optionally up to 10 weight-% of glycerol ditripalmitostearate and from about 10 to about 20 weight-% of microcrystalline cellulose and other conventional pharmaceutically acceptable adjuvants. A process for the manufacture of said tablets is described as well. n Said formulation is particularly suitable for the preparation of sustained release systems and in clinical tests it shows a bioavailability which is comparable with or superior to that of known commercial preparations. n The prolonged action of said tablets lasts up to 12 hours, which allows the administration of the drug twice a day. |