| abstract |
Pyridine-2,4-dicarboxylic acid derivatives of the formula I. in the R¹ halogen, carboxyl, C₁-C₄-alkoxycarbonyl, optionally substituted alkyl, alkenyl or alkynyl having up to 9 carbon atoms, optionally monosubstituted phenyl, naphthyl, thienyl, furyl, pyrrolyl or pyridyl, or a substituent of the formula -OR³ or -N (R³) ₂, where R³ is hydrogen or C₁-C₉-alkyl, C₁-C₉ alkenyl, C₁-C₉-alkynyl or C₁-C₉-alkylcarbonyl, these radicals optionally being mono- or disubstituted, and wherein the two substituents R³ in -N (R³) ₂ can also be different independently of one another means and R² is a substituent of the formula -OR⁴ or R⁴-N-R⁵, where R⁴ is hydrogen, optionally 1- or 2-fold substituted C₁-C₁₂-alkyl, optionally benzo-fused cyclohaxy or optionally substituted phenyl, naphthyl, thienyl, furyl, pyrrolyl or pyridyl and R⁵ is hydrogen or C₁-C₃-alkyl, optionally R⁵ in the case of C₁-C₃-alkyls together with R⁴, which in this case means C₃-C₅-alkyl, forming a heterocyclic, saturated 6-ring, the heterocyclic 6- Ring can also contain a second nitrogen atom and in turn can be substituted with phenyl or phenyl-C₁-C₃-alkyl means and where the two R 2 radicals bonded to the pyridine skeleton via the carbonyl group in the 2- and 4-position can also be different independently of one another, and all the alkyl radicals mentioned with more than 2 C atoms can also be branched, as well as the physiologically acceptable salts, a process for the preparation of the compounds of formula I and their use as medicaments, in particular as fibrosupressives and immunosuppressants. |