| abstract |
R 1 und R für Methyl, Ethyl, Isopropyl oder sek.-Butyl oder für die Gruppe - C=CH H-X stehen, worin X Methyl, Ethyl oder Isopropyl bedeutet und A und A' für die Gruppen stehen, worin R 2 Wasserstoff, -C(O)-CH 2 O-C(O)-CH 2 CH 2 -COOH oder -C(O)-CH 2 CH 2 -COOH bedeutet, oder von Gemischen von Verbindungen der Formeln 1 und II, das sich dadurch kennzeichnet, dass The present invention relates to a one-stage, microbial process for the preparation of 13β-hydroxy or 14.15-epoxy-milbemycins of the formulas I and II below wherein R 1 and R stand for methyl, ethyl, isopropyl or sec-butyl or for the group - C = CH HX, where X denotes methyl, ethyl or isopropyl and A and A 'for the group stand in what R 2 is hydrogen, -C (O) -CH 2 OC (O) -CH 2 CH 2 -COOH or -C (O) -CH 2 CH 2 -COOH, or of mixtures of compounds of the formulas 1 and II, the is characterized in that n n n a milbemycin of Fomel III dissolved in a liquid phase wherein R 3 is R 1 or R and R 4 is A or A 'and R 1 , R 1 , A and A' have the meanings given under the formulas I and II with one for 13β-hydroxylation or 14.15-epoxidation or brings microorganism or active components thereof capable of both reactions into contact. The microorganism or its active components can be present both in free and in immobilized form. |