| abstract |
The invention relates to compounds having the gener formula (I)n whereinn n is zero, 1 or 2; each of R 1 and R 2 is independently: a) hydrogen, halogen, trifluoromethyl or C 1 -Ce alkyl; b) hydroxy, C 1 -C 6 alkoxy or C 3 -C 4 alkenyloxy; c) nitro, amino, formylamino or C 2 -C 8 alkanoylamino; R 3 represents hydrogen or C 1 -C 8 alkyl; R 4 is: a') C 1 -C 20 alkyl, unsubstituted or substituted byn e') pyridyl, unsubstituted or substituted by one or two wherein each of R a and R b is Independently phenyl or C 1 -C 6 alkyl, or R a and R b , taken together with the nitrogen atom to which they are linked, form a N-pyrrolidinyl, N-piperazinyl, hexahydroazepin-1-yl, thiomorpholino, morpholino or piperidino ring, wherein said heterocyclic rings may be unsubstituted or substituted by C 1 -C 6 alkyl or phenyl; b') C 5 -C 10 cycloalkyl, unsubstituted or substituted by methyl; c') 2- or 3-pyrrolidinyl, piperidyl of 2-piperazinyl, wherein said heterocyclic rings may be unsubstituted or substituted by C 1 -C 6 alkyl; d') isoxazolyl or thiazolyl, wherein said heterocyclic rings may be unsubstituted or substituted by C 1 -C 6 alkyl; substituents chosen independently from halogen, C 1 -C 6 alkyl and C 1 -C 6 alkoxy; or f) phenyl, unsubstituted or substituted by one or two substituents chosen independently from halogen, CF 3 ,C 1 -C 6 alkyl, C 1 -C 6 alkoxy, amino, nitro, formylamino and C 2 -C 8 alkanoylamino, and the pharmaceutically acceptable salts thereof, which possess immunomodulating activity and are useful e.g. in the treatment of neoplastic diseases and acute and chronic infections of both bacterial and viral origin in mammals. |