| abstract |
The subject of the invention is peptide derivatives of formula X¹ - X² - Gly - Asp - X³ - X⁴ (I) in which X¹ represents hydrogen, an N-protecting group, an amino acid residue or an N-protected amino acid residue, X² represents a residue L-Arg or D-Arg, L-Orn or D-Orn, N-aminocarbonyl -L-Orn or N-amino carbonyl-D-Orn, or L-Lys or D-Lys, X³ represents an L-Trp, D-Trp, L-Leu, D-Leu, L-Ile, D-Ile, L-Phe, D-Phe residue or a chain of 2 or 3 of these residues, and X⁴ represents a group -OH, -NH₂, -OR¹ with R¹ representing a C₁ to C₄ alkyl radical, NHR² with R² representing a C₁ to C₄ alkyl radical, or an amino acid residue.n n n These derivatives are useful in therapy because of their anti-aggregating activity. |