| abstract |
Novel compounds of the formula (I), processes for their preparation and their use as collagenase inhibitors are described: .n in which R 1 is hydroxy; alkoxy; aryloxy; aralkyloxy; -NR 6 R 7 where R 6 and R 7 are hydrogen or alkyl, or R 6 and R 7 together with the N-atom to which they are bonded form a 5-to 7-membered ring with an optional heteroatom; -NHCH(R 8 )COR 9 where R 8 is hydrogen; alkyl optionally substituted by hydroxy, alkoxy, -NR 6 R 7 , quanidine, C0 2 H, CONH 2 , SH, or S-alkyl; or CH 2 -AR where Ar is optionally substituted aryl; and R 9 is hydroxy, alkoxy or -NR 6 R 7 . n R 2 is hydrogen or acyl. n R 3 is C 3-6 alkyl. n R 4 is hydrogen; alkyl; -CH 2 R 10 where R 10 is optionally substituted phenyl or heteroaryl; or -CH(R 12 )O-R 11 where R 11 is hydrogen; alkyl; or -CH 2 Ph where Ph is optionally substituted phenyl; and R 12 is hydrogen or alkyl. n R 5 is hydrogen; alkyl; or -CH(R 13 )COR 14 where R 13 is hydrogen or alkyl; and R 14 is hydroxy, alkoxy or -NR 6 R 7 . |