| abstract |
Isoindolin-1-one compounds represented by the following formula (I);n {wherein n represents an integer of 1 to 6; m represents 0 or 1; R 1 , R 2 and R 3 are each independently hydrogen or lower alkyl, and when m is 1, R, and one of R 2 and R 3 may form a five-membered or six-membered ring over N atom; X represents hydrogen or hydroxy; Ar represents naphthyl, pyridyl or substituted phenyl represented by the formula (II); Ar and X may form a lactone ring;n [wherein Y represents carboxyl, lower alkoxycarbonyl, carbamoyl, N,N-lower alkyl-substituted carbamoyl or amino represented by the formula (III):n (wherein Rs and R 7 are each independently hydrogen, lower alkyl or lower alkanoyl); R 4 and R 5 are each independently hydrogen, lower alkyl, cyano or halogen]} or a phrarmaceutically acceptable acid addition salt or metal salt thereof have an excellent antiarrhythmic activity. |