http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0272693-A2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_4f3768dbfdc2796afdffa2a799c10d84 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D211-90 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D409-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-06 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D211-90 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-451 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-445 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D409-06 |
| filingDate | 1987-12-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0bf59bb733f90540008416e1b8971a68 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_28ab91f87304986bb6ec76ca3cc723fb http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_475eb59078f877babf84a417529a19d7 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e930b27f804c9de41c10626cd92f839d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_506966656e4bf190d1c6d0171a68508e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c92f9d02871bdcbf028da17faec5878a |
| publicationDate | 1988-06-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-0272693-A2 |
| titleOfInvention | New aralkyl-1,4-dihydropyridines, a method for their preparation and pharmaceutical compositions containing them |
| abstract | 1,4-Dihydropyridines of formula I:n wherein: n- X is a -CO₂R₁, cyano, nitro, -COCH₃ group; n- R and R₁, that can be the same or different, are a primary, secondary or tertiary, saturated or unsaturated, linear or branched C₁-C₆ alkyl group that can be substituted or not by one or more hydroxy, C₁-C₇-monoalkylamino, di-C₁-C₇-alkylamino, benzylamino, C₁-C₆-alkoxy, phenoxy groups optionally substituted by one or more C₁-C₆ alkyl, C₁-C₆ alkoxy, halo-C₁-C₆ alkyl, halo-C₁-C₆-alkoxy, halogen, nitro, cyano, C₁-C₆ alkoxycarbonyl, C₁-C₆ alkylthio, NHCOR₅, SO₂R₆, C₁-C₄-alkylamino , di(C₁-C₄)alkylamino, hydroxy. n- R₂ is hydrogen; n- R₃ is hydrogen or a hydroxy, -OCOR₅, OSO₂R₆, azide, amino, -NHPO(OR₇)₂, -NHCOR₅ group, a C₁-C₄-alkoxy group or a fluorine, chlorine, bromine or iodine atom, a SH group, a SCOR₆ or a C₁-C₆-alkylthio, phenylthio or benzylthio group; n- R₄ is an optionally substituted aromatic or an optionally substituted 5- or 6-membered heteroaromatic group, containing one or more heteroatoms selected in the group of N,S,O, wherein the substituent is selected from one or more hydroxy, C₁-C₇-monoalkylamino, di-C₁-C₇-alkylamino, benzylamino, C₁-C₆-alkoxy, phenoxy groups optionally substituted by one or more C₁-C₆ alkyl, C₁-C₆ alkoxy, halo-C₁-C₆ alkyl, halo-C₁-C₆-alkoxy, halogen, nitro, cyano, C₁-C₆ alkoxycarbonyl, C₁-C₆ alkylthio, NHCOR₅, SO₂R₆, C₁-C₄-alkylamino , di(C₁-C₄)alkylamino, hydroxy; n- Y is one or more substituents, that can be the same or different, selected in the group of C₁-C₄-alkoxy, halogen, nitro, cyano, C₁-C₆-alkoxycarbonyl, C₁-C₆-alkylthio, halo-C₁-C₆-alkyl, halo-C₁-C₆-alkoxy, NHCOR₅ or NHSO₂R₆; n- R₅ is hydrogen or a C₁-C₄-alkyl, trihalomethyl, C₁-C₄-alkoxy or phenyl group, optionally substituted by one or more nitro, halogen, C₁-C₄ alkyl, C₁-C₄-alkoxy, amino groups; n- R₆is hydrogen or a C₁-C₄-alkyl, trihalomethyl, phenyl or p-methylphenyl group; n- R₇ is a C₁-C₄-alkyl group or a phenyl group; nare useful as antihypertensive, cytoprotecting or anti-ulcer agents. |
| priorityDate | 1986-12-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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