http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0270648-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ba4f31bd107def9877e9c7c9231cdc8e |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2123-00 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F9-3865 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K51-0489 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K51-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K51-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F9-38 |
| filingDate | 1987-06-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1ce2390f5344201bffe699933a5b6e4f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_53e280537602e70b0e5d9f83f9f79f43 |
| publicationDate | 1988-06-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-0270648-A1 |
| titleOfInvention | BONE-SEEKING COMPLEXES OF TECHNETIUM-99m |
| abstract | A composition for use in the preparation of a bone visualization agent comprises a mixture of a bisphosphonic acid of formula (I), wherein R1 and R3 may be the same or different groups selected from H, -SO3H and a lower aliphatic group optionally containing one or more hetero atoms and containing at least one -SO3H group; R2 is a group selected from H, -OH, -NH2, -NHMe, -NMe2 and lower alkyl optionally substituted by one or more polar groups; R4 is a group selected from H, -OH, -NH2, -NHMe, -NMe2, -SO3H and lower alkyl optionally substituted by one or more polar groups; n is 0 or 1; provided that when n is 0, R1 is not H and when n is 1, R1 and R3 cannot both be H. Also disclosed is a non-toxic salt of said composition, as well as a reducing agent for pertechnetate ions. Technetium-99m, in the form of an aqueous solution of pertechnetate ions, is added to the composition to form a complex of Tc-99m and bisphosphonate. This complex is useful as a bone tissue visualization agent and is rapidly absorbed by these tissues, giving high definition images. |
| priorityDate | 1986-06-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 90.