| abstract |
1-Aryloxy-4-[(4-aryl)-1-piperazinyl]-2-butanols of the formula:n wherein Ar is selected fromn or 2, 3 or 4-pyridyl); X and Xʹ are selected from the group of hydrogen, loweralkyl, loweralkoxy, halogen, trifluoromethyl, nitro, acetylamino, phenyl orn acetyl, cyano, aminocarbonyl, carboxy, or loweralkyl carboxylic acid ester; Y, Yʹ, Yʺ and Xʺ are selected from the same group as X and Xʹ except phenyl and substituted phenyl are excluded; Z and Zʹ are selected from hydrogen, loweralkyl or loweralkoxy and the pharmaceutically acceptable salt thereof are useful in inhibiting or combatting allergic response associated with anaphylactic sensitivity in animals and humans. |