| abstract |
The new imidazolium hydrogen carbonates of the general formula wherein the symbol Q arylene or heteroarylene, the group -NR¹R² a basic amino group, R³ hydrogen, lower alkyl, lower hydroxyalkyl, lower alkoxyalkyl, lower haloalkyl, lower alkylthio, lower alkoxy or the group - (A) n -Ra, R⁴ a saturated or partially unsaturated lower hydrocarbon group, a basic amino group or the group = CRc-Rb, -CHRcRd, -NH-CHRcRd, -NH-CO-Re or -CHRc-CO-Re, R⁵ hydrogen, lower alkyl, lower hydroxyalkyl, lower alkoxyalkyl , lower haloalkyl, aryl or a fused-on benzene ring, R⁶ hydrogen or lower alkyl, Ra and Rb each aryl, heteroaryl or a basic amino group, Rc hydrogen or lower alkyl, Rd aryl or heteroaryl, Re hydrogen, a saturated, optionally bonded via an oxygen atom or partially unsaturated lower hydrocarbon group or an aryl, heteroaryl or basic amino group, A vinylene or optionally bound via a lower alkyl group r lower Alkylene, n is the number 0 or 1 and the dashed line denotes an additional double bond, The corresponding pharmaceutically acceptable salts have valuable antibacterial, antifungal, protozoozide and / or anthelmintic properties. The imidazolium bicarbonates of the formula I can be used to produce such pharmaceutically acceptable, in particular water-soluble salts in a simple and inexpensive manner. |