| abstract |
A peptide derivative of the formula n nwherein A is hydrogen or a hydrocarbon acyl having 2 to 10 ncarbon atoms which may be substituted with an amino group, nB is Phe, Gly, Phe-Gly, Gly-Gly or Phe-Gly-Gly, C is a nneutral α-amino acid residue, and E is Gln, Gln-Ser or Gln-nSer-Gly, respectively or a salt thereof is useful as a nreagent for elucidating the morbid physiological role of αnhANP, and also used for the therapy of hypotension, nperipheral circulatory insufficiency of mammals (e.g. mice, nrats, rabbits, dogs, cats and humans, etc.). |