| abstract |
Hydantoin derivatives and salts thereof, intermediates therefor, process for the preparation thereof, and medicines containing the derivative, wherein said derivatives have the formulan wherein one of V and W is hydrogen and the other is a halogenomethyl group, 1 H-tetrazol-5-yl radical, -COOR group, n in which R is hydrogen atom, an alkyl group, -(CH 2 CH 2 O) n CH 3 group (n is an integer of 1 to 113) or substituted phenyl,n in which R 1 and R 2 are same or different independently, each is hydrogen atom, an alkyl group, substituted phenyl or -(CH 2 CH 2 O)nCH 3 group (n has the meaning as referred to) or R 1 may form a heterocyclic ring together with R 2 and nitogen or oxygen atom, n-CH 2 OR 3 group orn in which R 3 and Ra are same or different independently and each is hydrogen atom or an alkyl group, X is oxygen or sulfur atom, and Y and Z are same or different independently and each is hydrogen atom, a halogen atom, alkyl group, alkoxy group, alkylmercapto group, nitro radical or -NHR 5 group, in which R 5 is hydrogen atom or an acyl group. n The derivatives and salts thereof are useful for the treatment of complications of diabetes. |