| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_9e727909d17fde1129839931dba355e7 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-127
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-1271
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B82Y5-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-7048 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-70
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-127
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-133 |
| filingDate |
1987-08-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0cd59e0e4c93b83580e4079a6454c9a0
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d31d83a2cd79aaebf0d09520949a7cb2
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bce9135085f0cc9274b8c745b3cbf204 |
| publicationDate |
1988-03-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
EP-0260811-A2 |
| titleOfInvention |
Phospholipid particles encapsulating polyene antibiotics for the treatment of systemic fungal infections |
| abstract |
Formulations consisting of phospholipid small unilamellar particles encapsulating polyene antifungal antibiotics and methods for using such compositions to treat systemic fungal infections are described. In a preferred embodiment, the particles are in the form of vesicles which comprise a polyene antifungal antibiotic, preferably amphotericin B and/or nystatin, egg phosphatidylcholine and cholesterol, preferably in the molar ratio of about .2 (AMB):2(PLi:1(CHOL). These vesicles may also have an amine modified surface. The vesicles are suspended in a low ionic strength saccharide/tris solution at a pH of from about 6.0 to about 8.0 and may be administered to deliver the antifungal antibiotic to treat systemic fungal infections. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6406713-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-9004961-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5616334-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-9211841-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-4999199-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0270460-A2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6638913-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-9927940-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/FR-2620028-A2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-9726862-A2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-9726862-A3
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-9711683-A2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-9711683-A3
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0270460-A3 |
| priorityDate |
1986-08-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |