| abstract |
A 6-thioxanthine of general formula I or a pharmaceutically acceptable salt thereofn wherein R₃ is a C₂ to C₆ alkyl, a C₃ to C₇ cycloalkyl group or a C₄ to C₈ cycloalkylalkyl group and R₈ is a C₁ to C₆ alkyl, a C₃ to C₇ cycloalkyl group or a C₄ to C₈ cycloalkylalkyl group provided that when R₃ is an ethyl, n-propyl or n-butyl group, R₈ is a C₃ to C₆ alkyl, a C₃ to C₇ cycloalkyl group or a C₄ to C₈ cycloalkylalkyl group. n These 3,8-disubstituted-6-thioxanthines have enhanced bronchodilator activity. |