| abstract |
The subject of the present invention is new immunotoxins obtained by covalent coupling between, on the one hand trichosantine or trichokirine as it is or suitably modified and, on the other hand, an antibody or antibody fragment, used in its natural form or correctly modified, said coupling being carried out either via a disulfide bond, or via a thioether bond.n n n The subject of the present invention is also a process for the preparation of said immunotoxins and of pharmaceutical compositions containing them as active ingredient. |