| abstract |
5ʹ-guanylic acid (GMP) is produced by a process which comprises culturing in a medium a microorganism belonging to the genus Brevibacterium or Corynebacterium and having an ability to produce 5ʹ-xanthylic acid (XMP) and also an ability to reproduce 5ʹ-adenosine triphosphate (ATP) from 5ʹadenylic acid (AMP); bringing a microorganism belonging to the genus Brevibacterium , Corynebacterium , Klebsiella , Bacillus , Serratia or Escherichia and having an ability to form GMP from XMP, ammonia and/or glutamine, and ATP into contact with the resulting culture broth so as to covert the XMP to GMP by coupling reaction catalyzed by the two microorganisms; and recovering GMP from the culture broth. |