| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d0bf0e2b67d21b775ccc2a0b049599cd |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-6803
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-6889 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-532
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-531
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-395
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-48
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D239-95
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D475-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D475-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D475-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D475-08 |
| filingDate |
1987-05-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
1994-05-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c2d5335db718b68eb43fec22cc87d1d4
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fb862051f13da19a697882f2bef2c227
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_416c9a39aa894290e0f539205febe156
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_09bafc5db704c90d9ebe20ec29bec276 |
| publicationDate |
1994-05-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
EP-0251455-B1 |
| titleOfInvention |
Amine derivatives of folic acid analogs |
| abstract |
Novel therapeutic antibody conjugates comprising amine derivatives of folic acid analogs covalently attached via a reactive amine group to an oxidized carbohydrate moiety of an antibody or antibody fragment are disclosed. The conjugates retain substantially the same immunorespecificity and immunoreactivity of the unconjugated antibody molecule. The immunospecificity and immunoreactivity of the antibody conjugates permits targeted delivery of the attached therapeutically effective amine derivative of folic acid analogs in vivo. The conjugates are therapeutically effective against a variety of neoplastic and non-neoplastic cellular disorders when administered in vivo. Methods for synthesizing the amine derivatives of folic acid analogs, methods for preparing the antibody conjugates, and methods for use of the conjugates in vivo are also disclosed. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10046056-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10265416-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10265415-B2 |
| priorityDate |
1986-05-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |