| abstract |
Proteins are disclosed which react with the serum from an ATL (adult T-cell leukemia) patient but do not react with the serum from a healthy person. One type of protein contains pX-IV env gene products and it also reacts with anti p40 x monoclonal antibody. Its molecular weight is 59K. The other protein contains gag, pX-IV and env gene products and it also reacts with anti p19 and p28 monoclonal antibody in addition to anti p40 x monoclonal antibody. Its molecular weight is 100K. The production of the former protein utilises a plasmid constructed with lac promoter region, synthetic codon, and env and pX-IV gene regions, and the production of the latter protein utilises a plasmid having lac promoter region, synthetic codon, and gag, env, and pX-IV gene regions. These proteins are useful for detection of the antibodies of ATLA. |