| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_4826a707782225c8d80626e2273cfaee |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C08B37-0078 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P19-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P19-26
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08B37-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08B37-00 |
| filingDate |
1987-04-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_442479d4591694b1a657d5c6c19e71ec |
| publicationDate |
1987-11-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
EP-0244235-A2 |
| titleOfInvention |
Process for the preparation of LMW-Heparin |
| abstract |
A method for production of low molecular weight heparin (LMW-heparin) by enzymatic depolymerization of heparin with heparinase wherein heparin is continuously fed to a depolymerization zone, the depolymerized LMW-heparin is ultrafiltrated, the retentate is recycled to the depolymerization zone and LMW-heparin is recovered from the filtrate. The process enables the production of LMW-heparin with a desired molecular weight and low polydispersity within narrow limits by continuously or frequently measuring the molecular weight and polydispersity of the LMW-heparin product and correction of process parameters of the depolymerization reaction so as to counteract deviations in the molecular weight and polydispersity from the desired values. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6075013-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5744457-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5763427-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2021007429-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-111763702-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5767269-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5721357-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11542534-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-9855515-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/BE-1006827-A3
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-RE38743-E
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-0102443-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-9218544-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-102690862-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GR-910100270-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-2314632-A2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0511075-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/FR-2675806-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2022015794-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1792621-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6001820-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5707973-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6103705-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/FR-2663639-A1 |
| priorityDate |
1986-04-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |