| abstract |
Compounds of the general formula:n (wherein, R' and R 2 are, the same or different, hydrogen, a halogen, a lower alkyl, a cycloalkyl, a lower alkoxy, a phenylalkyloxy, or trifluoromethyl; R 3 is hydrogen or methyl; R' is carboxyl or an esterified carboxyl; and X is oxygen or sulfur), or a salt thereof, are novel compounds, possess aldose reductase inhibitory and platelet aggregation innibitory activities, and of use as drugs for prevention and treatment of diabetic complications such as diabetic cataract, retinophathy, nephropathy, and neuropathy. |