| abstract |
New 1-hydroxy-2-pyridones of the general formula I <IMAGE> in which R 1, R 2 and R 3, which are identical or different, denote hydrogen or lower alkyl having 1 to 4 carbon atoms, where R 1 and R 3 are preferably hydrogen and R 2 is preferably methyl , XS or preferably O, Y is hydrogen or up to 2 halogen atoms, namely chlorine and / or bromine, Z is a single bond or the divalent radicals O, S, -CR2- (R = H or C1-C4-alkyl) or others 2 -valent radicals with 2-10 chain-linked C and optionally O and / or S atoms, where - if the radicals contain 2 or more O and / or S atoms - the latter are separated from one another by at least 2 C atoms and where 2 adjacent C atoms can also be linked to one another by a double bond and the free valences of the C atoms are saturated by H and / or C1-C4-alkyl groups, Ar is an aromatic ring system with up to two rings, which is characterized by up to three residues from the group fluorine, chlorine, bromine, methoxy, C1-C4 -Alkyl, trifluoromethyl and trifluoromethoxy can be substituted, are prepared by different process variants. The compounds and their physiologically tolerable salts with inorganic or organic bases are mainly antifungal, antibacterial and antiviral. The compounds of the formula V <IMAGE> which occur in the preparation of the compounds of the formula I in which R 1, R 2, R 3, X, Y and Ar have the same meaning as in formula I are new. |