| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_63ec1c2b4dbe8f2a614546e85583758f |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2035-124
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2502-1394
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2533-30
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2533-40
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2533-70
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2510-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2502-1323 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-0669
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L27-60
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K35-28 |
| classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K35-12 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61L27-60
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K35-28
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-0789
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-00 |
| filingDate |
1986-08-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9dca2399c44fd2e461029ae6ab39918b
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ddbe666cfcad26977cdedc9e1581709f |
| publicationDate |
1987-10-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
EP-0241578-A2 |
| titleOfInvention |
Process for replicating bone marrow in vitro |
| abstract |
According to the present invention there is provided a process for replicating bone marrow cells in vitro . The process comprises the steps of: establishing a reticular fiber network by subsetting fibroblasts; conditioning a culture medium with secretory products of extramedullary macrophages and with secretory products of marrow stromal cells to produce a conditioned culture medium; providing the reticular fiber network within the conditioned culture medium; innoculating the conditioned culture medium with bone marrow cells, including hematopoeitic stem cells; and incubating the resulting modified culture thereby producing a replicated bone marrow containing hematopoietic stem cells having marrow repopulating activity. Replicated bone marrow produced by the process of this invention is useful in bone marrow transplants. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7192769-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-0045827-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5461034-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6548299-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-0027999-A2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7067316-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0343217-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0343217-A4
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6461645-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5192553-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6737051-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6569427-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6440734-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-0027999-A3
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/DE-3821922-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0349048-A2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6218505-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6605275-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0349048-A3
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5814610-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0384731-A2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6645489-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0384731-A3 |
| priorityDate |
1986-04-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |