| abstract |
Pharmaceutical compositions useful in regulating ncalcium transport across cellular membranes in man and aninmals are disclosed. The compositions contain plant growth nregulators such as abscisic acid and its derivatives. In nparticular, the compositions contain a compound of the fornmula: n nor nR₁ - Y - R₂ nwherein R₁ is an alkyl of up to seven carbons or a saturated nor unsaturated six membered carbon ring, which may be subnstituted; R₂ is a cyano group, a thio or hydroxy lower alkyl ngroup or a group containing a carbonyl, most commonly a ncarboxyl group; R₃ is hydrogen or lower alkyl; R₄ is hydrongen, lower alkyl or halide; R₅ is hydrogen or hydroxy; R₆ is nhydrogen, carboxy or carboxy lower alkyl, or R₅ and R₆ form na bond between the carbons to which they are attached or nwith the carbons to which they are attached form a carbon nring; or R₂ and R₆ together with the carbon to which they nare bonded form a heterocyclic ring; n is 0 or 1, with the nproviso that when n is 0, R₂ is an acyl group; X is -CH₂-, -nCH=CH-, -CH₂-CH₂-, -CH₂-NH-, -CH₂-O-, -CH₂-S- or -NH-CO-; nand Y is a carbocyclic group bonded to R₁ and R₂ through a nsingle carbon. The compositions are formulated for oral, n n nparenteral or other form of administration in dosages necesnsary to effect the desired change in calcium flux. Daily ndoses of 0.01 to 200 mg/kg in one or more doses are contemnplated. Dosage units may be formulated with any pharmanceutically acceptable carrier which is compatible with the nactive ingredient. |