| abstract |
Glycerol derivatives having at least one heterocyclic group on the 3 or 2 position and a group of formula -Y-D-Q on the 1 position (in which Y represents oxygen, sulphur, -NR<sup>3</sup>-, -X-CO-R'-, -R<sup>4</sup>-CO-X-, -NR'-CO-, -CO-NR<sup>3</sup>-or -X-P-(O) (OH)-O-, where -NR<sup>3</sup>-is optionally protected imino, R<sup>4</sup> represents a direct bond or -NR<sup>3</sup>; and X represents oxygen or sulphur; D represents optionally substituted C<sub>1</sub>-C<sub>14</sub> alkylene; and Q represents a nitrogen-containing heterocyclic group or an amino group either of which is optionally quatemized) are PAF antagonists which may be used to treat asthma, inflammation and shock. They may be prepared by reacting a glycerol derivative having an active group at the 1-position with an appropriate compound to introduce the desired group. |