http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0237983-A2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ed5d7d6320762d14957c5bea98e56d72 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P13-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P41-005 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P17-02 |
| classificationIPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12R1-72 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P41-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D303-40 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P13-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P17-02 |
| filingDate | 1987-03-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4f4b3db06244e6fafe6acbeb09b3c746 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5c99a72d91f6a394ef110b5330f2beaa http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6c5f593513424ffd930402b0cb313b3d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c40f6040c5de9c256f2af58469c07178 |
| publicationDate | 1987-09-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-0237983-A2 |
| titleOfInvention | Process for the biotechnological preparation of L (-)-carnitine chloride |
| abstract | Described is a process for the biotechnological preparation of L(-)-carnitine chloride having the formula (I) n<CHEM>n which comprises: n n a) reacting a racemic ester of (R,S)-3,4-epoxybutyric acid having formula (II): n<CHEM>n wherein R represents a C1-C10 alkyl group or a benzyl group, with an enzyme or with a microorganism producing said enzyme, capable of hydrolyzing asymmetrically and in a prevalent way enantiomer S(-), and in separating said enantiomer S(-) according to usual techniques from non-reacted ester (II) which is substantially present in the R(+) form; n b) reacting the R(+) form of ester (II) thus obtained with an enzyme capable of hydrolyzing said form R(+) quantitatively, under pH conditions controlled by means of alkalis, to obtain a salt of 3,4-epoxybutyric acid having formula (III) n<CHEM>n wherein X is e.g. Na, K, Li, substantially in the R(+) form and n c) reacting said R(+) form of the salt having formula (III) with trimethylamine in a molar excess and, after having removed said excess of trimethylamine by means of hydrochloric acid, thereby otaining L(-)-carnitine chloride having formula (I). L(-)-carnitine is an eutrophic and cardioprotecting agent for the cure of myocardic ischemia. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-9903850-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2011090812-A3 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0440723-B1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-0005227-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6284902-B1 |
| priorityDate | 1986-03-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 127.