http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0236163-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_116c851e729089df9a427027272fa290 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C255-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K5-06026 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K5-0606 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K5-06052 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K5-06078 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K5-06069 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K5-065 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K5-062 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K5-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D295-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C255-30 |
| filingDate | 1987-01-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a0448ac02b0247f78ded24c609aa5f74 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_dbea2ef59e6f369510a632394afd1796 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_11af7117c32c0b5d5971e5f7056d6469 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1dd6d2792f4367d10d2d0c5b534a821b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_08619eac75976e85684d6eb4577e74f2 |
| publicationDate | 1987-09-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-0236163-A1 |
| titleOfInvention | Derivatives of N-alpha-substituted N-alpha-arylsulfonylaminoacyl p-amidinophenylalaninamides, their preparation, their use as medicaments and their intermediates |
| abstract | The present invention relates to the compounds of formulan n n - Ri représente l'hydrogène, un groupe alcoyle inférieur, hydroxyalcoyle inférieur, benzyle, un groupe phényle ou un groupe hydroxy-4 phényle; - Rz représente un groupe alcoyle inférieur, alcényle inférieur, alcynyle inférieur, ou un groupe benzyle, ou un groupe alcoxycarbonylalcoyle inférieur, carboxyalcoyle inférieur, hydroxyalcoyle inférieur; ― R 3 et R 4 , identiques ou différents, représentent chacun un radical alcoyle ou hydroxyalcoyle inférieurs, alcényle inférieur, alcynyle inférieur ou forment ensemble, avec l'azote auquel ils sont attachés, un hétérocycle saturé tel que morpholino, thiomorpholino, pyrrolidino non substitué ou substitué par un groupe alcoxycarbonyle ou carboxy, pipérazino, (alcoyle inférieur)-4 pipérazino, (hydroxyalcoyle inférieur)-4 pipérazino, ou pipéridino non substitué ou substitué par un groupe alcoyle inférieur, benzyle, hydroxy, hydroxyalcoyle inférieur, amino, aminoalcoyle inférieur, hydroxyamino, alcoxycarbonyle ou carboxy. - Ar représente un groupe phényle, alpha-naphthyle ou béta-naphthyle, éventuellement substitués, ou bien un groupe hétéroaryle choisi parmi les radicaux pyridyle, quinoléinyle, isoquinoléinyle, éventuellement substitués, ainsi que leurs isomères et leurs mélanges et leurs sels avec les acides minéraux ou organiques pharmaceutiquement acceptables. in which: - R 1 represents hydrogen, a lower alkyl group, lower hydroxyalkyl, benzyl, a phenyl group or a 4-hydroxy phenyl group; - Rz represents a lower alkyl group, lower alkenyl, lower alkynyl, or a benzyl group, or a lower alkoxycarbonylalkyl group, lower carboxyalkyl, lower hydroxyalkyl; - R 3 and R 4 , identical or different, each represent a lower alkyl or hydroxyalkyl radical, lower alkenyl, lower alkynyl or together form, with the nitrogen to which they are attached, a saturated heterocycle such as morpholino, thiomorpholino, pyrrolidino unsubstituted or substituted by an alkoxycarbonyl or carboxy group, piperazino, (lower alkyl) -4 piperazino, (lower hydroxyalkyl) -4 piperazino, or piperidino unsubstituted or substituted by a lower alkyl group, benzyl, hydroxy, lower hydroxyalkyl, amino, lower aminoalkyl , hydroxyamino, alkoxycarbonyl or carboxy. - Ar represents a phenyl, alpha-naphthyl or beta-naphthyl group, optionally substituted, or else a heteroaryl group chosen from pyridyl, quinoline, isoquinoline radical, optionally substituted, as well as their isomers and their mixtures and their salts with mineral acids or pharmaceutically acceptable organic. n n n The invention also relates to a process for preparing the products of formula (I), their application as a medicament and the intermediate compounds for their synthesis. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6984627-B1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7538111-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0614911-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6214800-B1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0558961-A3 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-9605189-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0508220-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6486129-B1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6551999-B1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5457114-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5489583-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0513543-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-9301208-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1067136-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6057290-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0558961-A2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5674890-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0623596-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0623595-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/FR-2701480-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5274098-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5714497-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0771565-A3 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-9429336-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5506258-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0603112-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-9965934-A1 |
| priorityDate | 1986-01-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 296.