| abstract |
Disclosed are novel carbapenem derivatives characterized by a non-hydrogen substituent in the 1-position of the carbapenem ring and a 2-substituent of the formula n in which A represents cyclopentylene, cyclohexylene or C 2 -C 6 alkylene optionally substituted by one or more C 1 -C 4 alkyl groups; R 5 represents either (a) an optionally substituted aliphatic, cycloaliphatic, cycloaliphatic-aliphatic, aryl, araliphatic, heteroaryl, heteroaraliphatic, heterocyclyl or heterocyclyl-aliphatic radical or (b) a divalent phenylene or C 1 -C 4 alkylene group joined to the n ring so as to form a bridged polycyclic group; and n represents a quaternized nitrogen-containing non-aromatic heterocycle. Such derivatives are useful as potent antibacterial agents. |