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filingDate 1986-12-22-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationDate 1990-01-17-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber EP-0235463-A3
titleOfInvention N-substituted-arylalkyl and arylalkylene piperidines as cardiovascular antihistaminic and antisecretory agents
abstract Cardiovascular disturbances and the effects of hista­nmine and excessive gastric secretion can be countered by ncompounds expressed generally by the formula: n nwherein; np is zero, one or two; nm is one to six inclusive; nA is hydrogen, -O-R¹, -C≡N, -(O)NR¹R², -C(O)R¹, n-C(O)-OR¹, -CH₂OR¹, -CH₂NR¹R², or -OC(O)R¹; n nd and n are zero or one and the dotted lines represent ndouble bonds which may form consistent with the valence of ncarbon; nB is O, S, -S(O)-, -S(O)₂-, --, and --C(O)OR¹; n Ar, D and R are selected from phenyl and substituted nphenyl with certain limitations, pyridinyl, thienyl, furanyl or nnaphthyl and, in addition, R may have the values: benzyl, nsubstituted benzyl, cycloalkyl or loweralkyl, and D may nadditionally have the values:2H-1-benzopyran-2-one,4-oxo-­n4H-benzopyran-2-carboxylic acid loweralkyl ester, 1,4-­nbenzodioxanloweralkyl-2-yl or quinolinyl, and the phar­nmaceutically acceptable addition salts thereof.
priorityDate 1985-12-20-04:00^^<http://www.w3.org/2001/XMLSchema#date>
type http://data.epo.org/linked-data/def/patent/Publication

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