http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0230718-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a8659631bf38b3a590c0d3edc265492c |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D211-58 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D451-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-46 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D211-58 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D451-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P1-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-445 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4468 |
| filingDate | 1986-10-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5faabb4e38f371dc9dc44a82d35d30fb http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_172ee9778f72671b8011443fcc1c7385 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_19149901332884dcba1655f582bc0b7d |
| publicationDate | 1987-08-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-0230718-A1 |
| titleOfInvention | Substituted benzamides and benzoates |
| abstract | Compounds of formula (I) and pharmaceutically acceptable salts thereof:wherein: Ar is a group of formula (a):wherein either R<sub>2</sub> is C<sub>1-6</sub> alkoxy and one of R<sub>3</sub>, R<sub>4</sub> and R<sub>5</sub> is hydrogen and the other two are selected from hydrogen, halogen, CF<sub>3</sub>, C<sub>1-6</sub> alkylthio, C<sub>1-7</sub> acyl, C<sub>1-10</sub> carboxylic acylamino, C<sub>1-6</sub> alkyl S(0)n wherein n is 1 or 2, nitro or amino, aminocarbonyl or aminosulphonyl optionally substituted by one or two groups selected from C<sub>1-6</sub> alkyl, C<sub>3-8</sub> cycloalkyl, C<sub>3-8</sub> cycloalkyl C<sub>1-4</sub> alkyl or phenyl C<sub>1-4</sub> alkyl groups any of which phenyl moieties may be substituted by one or two groups selected from halogen, CF<sub>3</sub>, C<sub>1-6</sub> alkyl or C<sub>1-6</sub> alkoxy; or R<sub>2</sub> is hydrogen and R<sub>3</sub>, R<sub>4</sub> and R<sub>6</sub> are independently selected from hydrogen, C<sub>1-6</sub> alkyl, hydroxy, C<sub>1-6</sub> alkoxy, C<sub>1-6</sub> alkylthio or halo; or any two on adjacent carbon atoms together are C<sub>1-2</sub> alkylenedioxy and the third is hydrogen, C<sub>1-6</sub> alkyl, C<sub>1-6</sub> alkoxy or halo; or Ar is a group of formula (b):wherein W is CH,, 0, S or NR<sub>7</sub> wherein R<sub>7</sub> is hydrogen, C<sub>1-6</sub> alkyl C<sub>3-7</sub> alkenyl-methyl, phenyl or phenyl C<sub>1-4</sub> alkyl either of which phenyl moieties may be substituted by one or two of halogen, CF<sub>3</sub>, C<sub>1-6</sub> alkoxy or C<sub>1-6</sub> alkyl; and V is CH or N; orW is CH or N and V is NR, where R<sub>a</sub> is as defined for R<sub>7</sub> above or CHR<sub>c</sub> where R<sub>c</sub> is as defined for R<sub>e</sub> below;R<sub>b</sub> is present when the COX linkage is attached at the phenyl ring, and is selected from hydrogen, halogen CF<sub>3</sub>, hydroxy, C<sub>1-6</sub> alkoxy or C<sub>1-6</sub> alkyl;R<sub>6</sub> is hydrogen, halogen, CF<sub>3</sub>, C<sub>1-6</sub> alkyl, C<sub>1-6</sub> alkoxy, C<sub>1-6</sub> alkylthio, C<sub>1-7</sub> acyl, C<sub>1-7</sub> acylamino, C<sub>1-6</sub> alkylsulphonylamino, N-(C<sub>1-6</sub> alkylsulphonyl)-N-C<sub>1-4</sub> alkylamino, C<sub>1-6</sub> alkylsulphinyl, hydroxy, nitro or amino, aminocarbonyl, aminosulphonyl, aminosulphonylamino or N-(aminosulphonyl)-C<sub>1-4</sub> alkylamino optionally N-substituted by one or two groups selected from C<sub>1-6</sub> alkyl, C<sub>3-8</sub> cycloalkyl C<sub>3-8</sub> cycloalkyl C<sub>1-4</sub>alkyl, phenyl or phenyl C<sub>1-4</sub> alkyl groups or optionally N-disubstituted by C<sub>4-6</sub> polymethylene;X is NH; or 0 when Ar is of formula (a) and R<sub>2</sub> is hydrogen, or when Ar is a group of formula (b);Y is a group of formula (c), (d) or (e): wherein p and q are independently 0 or 1;Z is C<sub>2</sub> or C<sub>3</sub> polymethylene optionally substituted by one or two C<sub>1-4</sub> alkyl groups; andR, is hydrogen or C<sub>1-6</sub> alkyl or OR, is an in vivo hydrolysable acyloxy group; having gastric motility enhancing activity, anti-emetic activity and/or 5-HT receptor antagonist activity, a process for their preparation and their use as pharmaceuticals. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5262418-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5227377-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5234921-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5185335-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5260303-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2006069125-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5196547-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5166341-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5126343-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5219850-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5223613-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5137893-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5140023-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-9214727-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6069152-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5204356-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5438064-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0454121-A2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5612366-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6117882-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5434161-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-RE35218-E http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5627190-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0358903-A3 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2005080389-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0501322-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0640601-A4 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5604239-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5591749-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0454121-A3 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5516782-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-4883803-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5411968-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0908459-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5280029-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0640601-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5352685-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0358903-A2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5374637-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5500422-A |
| priorityDate | 1985-11-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 177.