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filingDate 1986-12-24-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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publicationDate 1987-07-29-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber EP-0230144-A1
titleOfInvention Flow reactor system
abstract Reactions can be carried out at temperatures of -50°C or below with residence times of 1 minute or less using a novel low temperature, continuous flow-reactor system. The system comprises a closed tubular thermally conductive flow reactor (1) having at least two inlet ports (2) and an outlet port (17); respective fluid supply conduits (13,14) communicating with the inlet ports (12); a fluid outlet conduit (18) communicating with the outlet port (17); pump means (31,32) for controlling the flow of fluid through the flow reactor; and a cooling zone (25,26) accommodating the reactor (1). At least one of the fluid supply conduits (13,14) is thermally conductive and is coiled proximate to but spaced from said flow reactor (1) in the cooling zone. Preferably, the coiled portion of the fluid supply conduit is coiled around but spaced from the flow reactor. n Conveniently, the flow reactor has a right circular reaction chamber formed by a tubular main body having a circular recess closed by a cover plate. n The system is particularly useful for the production of ethyl 2,2-difluoro-4-pentenoate by the spontaneous rearrangement of 1,2,2-trifluorovinyl allyl ether in the presence of ethanol and for the production of 2-fluorinated methyl aminoacetonitriles by reaction of a fluorinated methyl ketimine magnesium halide salt with hydrogen cyanide, or aqueous ammonium cyanide, or an aqueous solution of an alkali metal cyanide and a proton source.
priorityDate 1985-12-31-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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