| abstract |
The invention relates to compounds of the formula: <IMAGE> wherein Z is oxygen or sulfur, R is hydrogen or lower alkyl, R1 is hydrogen, lower alkyl or aryl-lower alkyl, R2 is hydrogen, lower alkyl or aryl-lower alkyl or R1 and R2 are together alkylene with 4-6 C atoms, R3 is hydrogen , Hydroxy, lower alkoxy, aryl-lower alkoxy, acyloxy or aryloxy in compounds with the meaning sulfur for Z, R3 Hydroxy, lower alkoxy, aryl-lower alkoxy, acyloxy or aryloxy in compounds with the meaning oxygen for Z and R3 in 5 or 8 position is bound in compounds with the meaning oxygen for Z, R4 and R5 independently of one another are hydrogen, lower alkyl or halogen, and pharmaceutically acceptable salts thereof, mono- or di-S-oxides of compounds of the formula I in which Z is sulfur. The compounds can be used as modulators for the receptors of the central nervous system, e.g. B. as serotonin receptor antagonists in the treatment of disorders of the central nervous system. |