| abstract |
This invention relates to the novel selenium compounds which are useful as an antineoplastic agent. The compounds are represented by the general formula (1):n wherein R, X, A and Y represent the groups specified below, a represents a number of 0 or 1, b represents a number of 0, 1 or 2, and (1) when a is 0 and b is also 0, c is 4, n is 1 or 2 and m is 0, (2) when a is 1 and b is 0, c is 2, n is 1 or 2 and m is 0 or 1, and (3) when b is 1 or 2, c, n and m are all 0;n (i) when b is 2, R represents (1) a C 4-10 alkoxy group substituted with a halogen atom, (2) a lower alkoxyl group substituted with a halogen atom and a phenyl group, or (3) a cycloalkyloxy group substituted with a halogen atom, and (ii) when b is 1, R represents a group represented by the formulan (wherein R o is a C 2-6 alkyl group); X represents a halogen atom; A represents caffeine, theophylline, N-benzyltheophylline, N-benzyltheobromine, 2,2'-biquinoline, 1,6-naphthylidine, 1,10-phenanthroline, or a compound represented by the formulan orn (wherein R, and R 2 may be the same or different and represent a hydrogen atom, a hydroxyl group, a lower alkyl group, a halogen atom, a phenyl group, a cyano group, a lower alkoxycarbonyl group, a phenoxycarbonyl group, an amino group (to which a lower alkyl, lower alkylaminocarbonyl, lower halogenoalkylaminocarbonyl or lower alkoxycarbonyl group may be bonded), a benzoyl group, a loweralkoxyl group, a carbamyl group or an allyloxycarbonyl group; R 3 represents a C 1-10 alkyl group or a benzyl group; R. and R 5 represent independently a hydrogen atom, a halogen atom or an alkyl group, or R 4 and R 5 may representn in combination; R 6 represents a lower alkoxyl group, a phenyl group or a phenoxy group; R 7 represents a hydrogen atom, a lower alkyl group or a group represented by the formulan (wherein R 9 represents an amino group or a lower alkoxyl group); R 10 represent a hydrogen atom or a nitro group; and one of B and D represents nitrogen and the other represents ≥C-H or ≥C-OH); and Y represents H 2 O or an alcohol represented by the formula R 8 -OH [wherein R 8 represents a benzyl (which may be substituted with a lower alkoxy group) or alkyl group]; wherein when X is chlorine atom and m is 0, R 1 and R 10 represent an atom or a group other than hydrogen atom. |