| abstract |
Novel 3-aminocarbonyl-1,4-dihydropyridine-5-carboxylic acid compounds of the formula: wherein R¹ is H, C<sub>1-5</sub> alkyl, C<sub>2-5</sub> alkenyl, C<sub>3-5</sub> alkynyl, C<sub>3-8</sub> cycloalkyl, R² is C<sub>1-10</sub> alkyl, and the NO₂ group is substituted at ortho- or meta-position, provided that when the NO₂ group is substituted at ortho-position and R² is methyl, R¹ is C<sub>3-5</sub> alkyl, C<sub>2-5</sub> alkenyl, C<sub>3-5</sub> alkynyl, or C<sub>3-8</sub> cycloalkyl, and when the NO₂ group is substituted at meta-position and R¹ is H, R² is C<sub>3-10</sub> alkyl, which have excellent hypotensive, vasodilating activities and in pharmaceutical compositions are useful for the prophylaxis and treatment of hypertension, ischemic heart diseases and cerebral and peripheral circulation diseases. Also process for preparing these compounds and their use are disclosed. |