| abstract |
Compounds of the formulae la, Ib and Icn whereinn X is 0, S, NH or NR; R is alkyl, alkenyl, alkynyl, cycloalkyl, aromatic-ring-alkyl all of which may be optionally interrupted by a herero atom: OH; an aromatic ring; or the group -C(=NH)-NH 2 ; R 1 is optionally substituted and selected from a carboxylic aromatic and a heterocyclic group which heterocyclic group is aromatic, partially saturated or fully saturated, the optional substituent of R 1 being halogen, alkyl, haloalkyl, OH, alkoxy, hydroxyalkyl, amino, mono- or di-alkylamino, carbalkoxy, carbamoyl and alkylcarbamoyl; R 2 is H, alkyl, hydroxy-C 2 -C 4 -alkyl, alkenyl, arylalkyl, or arylalkenyl; A is a bivalent bridging group containing chain atoms selected from C, 0, N and S thus forming together with the two adjacent carbon atoms to which the chain is attached a mono- or bicyclic carbocyclic or heterocyclic group with the proviso that a monocyclic group formed by A is saturated or partially saturated and that the ring moiety adjacent to the triazolopyrimidine structure in a bicyclic, carbocyclic or heterocyclic group is other than carbocyclic aromatic, and A is optionally substituted by substituents from the group consisting of alkyl. alkoxy, hydroxy, halogen, haloalkyl, N02, NH 2 , lower alkylthio. lower alkylsulfonyl, lower alkylsulfinyl, aryl-lower alkyl, amido. carbamoyl, carbalkoxy or aroyl; and pharmaceutically acceptable salts thereof. |