| abstract |
There are described compounds of formula I,n in which Y is S, 0 or NR 9 ,n n is 0 or 1, R 9 is hydrogen or alkyl C 1 to 10, R 3 is hydrogen, alkyl C 1 to 10, cycloalkyl C3 to 10, CF 3 , SR 10 , a 5 or 6 membered heterocyclic group containing one or more S, O or N atoms, NR 4 R 5 , phenyl or phenylalkyl C7 to 12, the phenyl, phenylalkyl and heterocyclic groups optionally being fused to a further phenyl group, the heterocyclic group and any phenyl group optionally being substituted by alkyl C 1 to 6, halogen, alkoxy C 1 to 6, nitro, nitrile, CF 3 , SR 6 , NR 7 R 11 or hydroxy, R 6 , R 7 and R,,, which may be the same or different, are each hydrogen or alkyl C 1 to 10, R, and R s , which may be the same or different, are each hydrogen, alkyl C 1 to 10 or phenyl, R, 10 is alkyl C 1 to 10, X, is S or 0, and D is a chain comprising from 2 -16 atoms, which chain carries an O or S containing substituent at a position 2 -6 atoms away from the group C=X,, and pharmaceutically acceptable salts, esters and amides thereof, there are also described methods for making the compounds and pharmaceutical formulations, eg for the treatment of hypertension, containing them. |