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filingDate 1983-05-20-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationDate 1989-02-01-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber EP-0213391-A3
titleOfInvention Antigenic modification of polypeptides
abstract Modified polypeptides capable of provoking the form­nation of antibodies in an animal may be produced by forming na linear polymer of polypeptide fragments, each having a nmolecular structure similar to a fragment of the protein to nwhich antibodies are to be provoked. Such linear polymers ncan be made more immunogenic than the proteins to which nthey are related without introducing undesirable extraneous nmaterials into the animal being treated, but have reproduc­nable immunogenic properties. Protein which are not endoge­nnous or immunogenic to an animal can be chemically modi­nfied so as to make them more immunogenic. Also, modified nantigens useful for fertility control can be produced by chemi­ncal modification of zona pellucida or sperm antigens. These nmodified polypeptides, antigens and modified antigens are ndesirably administered in the form of a vaccine having a veh­nicle comprising a mixture of mannide monooleate with nSqualene and/or Squalene.
priorityDate 1983-03-04-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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