| Predicate |
Object |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-525 |
| classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12R1-19 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N1-20
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P21-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-09
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-19
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-52
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-525
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-57
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-555
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-00 |
| filingDate |
1986-02-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
1990-07-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate |
1990-07-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
EP-0213175-B1 |
| titleOfInvention |
Cysteine-depleted muteins of biologically active human tumor necrosis factor proteins |
| abstract |
Synthetic muteins of biologically active human tumor necrosis factor (hTNF) wherein at least one of the two cysteine residues is deleted or replaced by another amino acid to eliminate sites for intermolecular crosslinking. The invention also relates to synthetic structural genes having DNA sequences that have been specifically designed to encode the above-described synthetic hTNF muteins. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6171577-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5968477-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7744853-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7115248-B2 |
| priorityDate |
1985-02-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |