http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0211043-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_1721d75f5bf603447ec5a26b5c1c0be0 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H21-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F15-065 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H23-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6816 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-68 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F15-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-68 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H23-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H21-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-04 |
| filingDate | 1986-01-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_10449bbc12ed82269c6c091d9eb2b847 |
| publicationDate | 1987-02-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-0211043-A1 |
| titleOfInvention | Chemical probes for left-handed dna and chiral metal complexes as z-specific antitumor agents |
| abstract | Disclosed are a complex and coordination salts, and optically resolved enantiomers thereof, having the formula (R)3---M, wherein R comprises 1,10-phenanthroline or a substituted derivative thereof , M comprises a suitable transition metal, for example ruthenium (II) or cobalt (III), and R is linked to M by a coordinate bond. These complexes are useful in DNA labeling, nicking and cleaving methods. The lambda enantiomer of these compounds is useful in specific Z-DNA labeling, detection, nicking and cleavage methods. These compounds can also be used in a method of destroying tumor cells, and can be combined with a pharmaceutically acceptable excipient to form a pharmaceutical composition for treating tumor cells in a patient. The invention further relates to methods of treating a patient with tumor cells. |
| priorityDate | 1985-01-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 199.