http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0209541-B1
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H15-252 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H15-252 |
| filingDate | 1985-12-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 1989-10-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1989-10-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-0209541-B1 |
| titleOfInvention | Open chain-morpholino adriamycins |
| abstract | Compounds of formula (I) and the pharmaceutically acceptable salts thereof wherein R is: -CO-CH3, -CHOH-CH3, -CO-CH2OH, -CHOH-CH2OH, hydrogen, hydroxy, 1 to 3 carbon alkyl, 1 to 3 carbon terminal hydroxyalkyl; or, a 2 to 7 carbon ester or diester of said -CO-CH2OH, -CHOH-CH2OH, -CHOH-CH3 or of said 1 to 3 carbon terminal hydroxyalkyl; or said -CO-CH2OH, -CHOH-CH2OH, or -CHOH-CH3 or said 1 to 3 C-terminal hydroxyalkyl having 1 to 6 carbon alkyl or aryl ether replacements of one or more of the hydroxyls; or the 13-ketimine derivatives of -CO-CH3 and -CO-CH2OH; Y is hydrogen, hydroxy, or methoxy, X is O or NH, but when Y is hydrogen or hydroxy, X must be O; at least one of R1 and R2 is hydrogen and the other is hydrogen, hydroxy, or methoxy; B is H, alkyl or optionally substituted aryl lower alkyl, said alkyl or optionally substituted aryl lower alkyl also optionally containing hydroxy, alkoxy, carbonyl, cyano or ester group substitutions; or B and R2 taken together, in order, are the methylene-oxygen bridge -CH2-O-; and A is -CHR3CN wherein R3 is H, optionally substituted aryl, alkyl or optionally substituted aryl lower alkyl, said alkyl or optionally substituted aryl lower alkyl optionally containing hydroxy, alkoxy, carbonyl, or ester group substitutions. These compounds are useful anti-tumor agents. |
| priorityDate | 1985-01-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 146.