| abstract |
A 21-substituted thiosteroid represented by the general formulawhereinR<sup>1</sup> represents an alkyl group having 1 to 6 carbon atoms, a cycloalkyl group having 5 or 6 carbon atoms, a phenyl group, or a benzyl group which may have a substituent on the benzene ring,R<sup>2</sup> represents an alkanoyl group having 2 to 6 carbon atoms,R<sup>3</sup> represents a hydrogen atom or a methyl group,X represents a hydrogen or halogen atom, andthe dotted line between 1- and 2-positions represents an optional bond. These compounds are useful as anti-inflammatory agent. |