| abstract |
Precursor polypeptide having the amino acid sequence: met-gln-arg-pro-phe-leu-leu-ala-tyr-leu-val-leu-ser-leu-leu-phe-asn-ser-ala-leu- gly-X, where X is a polypetid. The precursor polypeptide, when produced in a eukaryotic host cell by expression of a gene encoding the precursor polypeptide, is exported from the host cell and processed to produce the mature polypeptide X. The polypeptide can be an enzyme, a lymphokine, a hormone or the like. The yeast enzyme AMG, mammalian interferon-2 polypeptides, and gastric lipase are specifically described by way of example. |